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Other options include insulin therapy (if glycaemic targets are not met with oral agents), pioglitazone (though weight gain is common), or optimising existing metformin therapy

Exenatide formulations show variable nausea rates: the twice-daily immediate-release preparation (Byetta) tends to produce higher rates of nausea (approximately 3050%), whilst the once-weekly extended-release formulation (Bydureon) demonstrates improved tolerability with nausea rates of approximately 1424%, according to their respective SmPCs

Liraglutide, sold as Saxenda, is a GLP-1 agonist like semaglutide but needs daily injections instead of weekly

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Yet reports suggest some individuals are already seeking it through unofficial routes