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Our findings reveal that exendin-4 and liraglutide significantly reduce hepatic cholesterol accumulation and suppress SREBP-2 expression, a crucial regulator of cholesterol metabolism, via activation of the SIRT6-AMPK pathway in PA-treated HepG2 cells

Study design and baseline profile for adults with type 2 diabetes in the once-weekly subcutaneous SEmaglutide randomized PRAgmatic (SEPRA) trial

Metformin reduces blood glucose levels primarily by suppressing hepatic glucose production and improving how much sugar the body processes through enhanced insulin sensitivity

[DOI] [PubMed] [Google Scholar] 16.Hadgu R, Worede A, Ambachew S