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This was not about a contaminated drug, Brunner said about the overdosing warning

Of the weight lost, the reduction in lean body mass (body components excluding fat, such as muscle, bone and water) accounted for only 10.8%

The weight loss potential of semaglutide GLP-1 injections typically falls within the 15-20% range of initial body weight, with outcomes varying based on a few things like the weight youre starting at, metabolism, compliance with the regimen, dietary habits, exercise routine, and overall health condition

doi:10.1111/dom.16504 U.S

This doesnt mean the drug fails, but it shows why long-term dependency is a risk, especially for non-diabetics