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Adherence and Success in Long-Term Weight Loss Diets: The Dietary Intervention Randomized Controlled Trial (DIRECT) J

High insulin levels can trigger the ovaries to produce too many androgens, which disrupt normal follicle development and ovulation

The MAD evaluated doses ranging from 140 mg to 420 mg administered every 4 weeks on days 1, 29 and 57

Pirro V, Roth KD, Lin Y, Willency JA, Milligan PL, Wilson JM, Ruotolo G, Haupt A, Newgard CB, Duffin KL

Animal studies support this hypothesis, showing lower levels of inflammation and improved muscle fiber ratio, area, and density in obese mice administered semaglutide (79)