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Professional societies: Recommend discontinuation at least 2 months prior to conception

This rapid excretion occurred independent of changes in the levels of circulating regulators of plasma volume, including atrial natriuretic peptide (ANP) and aldosterone, and a similar phenomenon has also been suggested for the excretion of electrolytes including potassium (18)

The increase in PKA activity also leads to closure of ATP-sensitive potassium channels, which in turn causes depolarisation of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of secretory granules and thus secretion of insulin

Int J Obes (Lond) 2007;31(5):743750

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