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Yesterday, Novo Nordisk announced that a new weight loss shot it hoped would rival Eli Lillys injectable actually underperformed in a head-to-head trial, tanking Novos stock

Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)

Patients discontinuing GLP-1 medications should monitor for signs of gallbladder problems (severe abdominal pain, especially after meals), pancreatitis (persistent severe abdominal pain, sometimes with vomiting), or significant hyperglycemia

-endorphin expression was mediated through autocrine activation of the IL-10 receptor- and downstream phosphorylation of STAT3 [63]

GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and the blahs Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Common GLP-1 Side Effects and How to Manage Them Most side effects show up early, often within the first few days of beginning GLP-1 treatment