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Provider: A more streamlined regimen could facilitate titration and shared decision-making while moving towards A1c goals

Preclinical studies demonstrate that microglial activation within the spinal cord primarily mediates pain hypersensitivity in males, whereas females depend more on T celldriven immune signaling to maintain neuropathic pain states (Mogil et al., 2024

While the safety and effectiveness of semaglutide in children have not been established, it is typically not recommended for individuals under 18 years of age

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Treatment is usually started at a lower strength before gradually increasing to the maintenance dose
