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Topical NSAIDs (such as ibuprofen gel) are recommended by NICE as first-line for localised joint pain

Pendulum GLP-1 Probiotic makes sense if appetite regulation through GLP-1 support is your specific focus
Less Recognized Adverse Effects A common finding amongst all GLP-1 trials was that of increased heart rate attributed to a direct effect on the pacemaker cells within the sinus node of the heart [185]
[DOI] [PubMed] [Google Scholar] 216.Zhang Y.L., et al

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