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05/22/2026 References * Obesity Medicine Association ** American Association of Clinical Endocrinology *** American Board of Obesity Medicine 1

Consequently, maintaining the therapeutic effects of GLP-1R agonism requires a long-term dosing regimen, much like medications used for other chronic conditions, such as statins for cholesterol control, ACE inhibitors and beta-blockers for blood pressure, or warfarin for blood thinning

Notably, the percentage of patients discontinuing treatment escalates significantly when initial weight loss results fail to meet expectations

Because Alzheimers disease and dementia risk are closely connected to insulin resistance, vascular health, inflammation, and metabolic dysfunction, researchers are asking whether GLP-1 signaling may influence brain aging

Individuals with severe kidney disease: GLP-1 medications can sometimes affect kidney function