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SIBO-related nutrient depletion compounds these effects further

P., Astrup A., Finer N., et al., Effect of Sibutramine on Weight Maintenance After Weight Loss: A Randomised Trial, Lancet 356, no

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Symptomatic relief strategies include: Cold compresses : Applying a clean, cool (not ice-cold) compress to the injection site for 10-15 minutes can reduce inflammation, constrict blood vessels to decrease redness, and provide soothing relief from itching

The Phase 3 TRIUMPH-4 trial has reported even more impressive results, with participants achieving up to 28.7% body weight reduction