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Initial weight loss in week 1 is usually water weight from reduced food intake and decreased stomach distention, typically 12 pounds

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long after the meds are done

however, when rigorously designed using proven analytic approaches to emulate reference trials, real-world evidence of several glucose-lowering drug classes have demonstrated strong concordance with trial estimates 20,22,32

Risk factors associated with NAION can include diabetes, hypertension, sleep apnea, vascular disease, and other conditions affecting blood circulation and optic nerve health