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But with the current ubiquity of easy dispensing options, can we ever put the genie back in the bottle

These medications work on the output side

If tolerating well with no GI issues and no hypoglycemia signals, increase to 500mg twice daily with two meals

GLP-1 receptor agonists work by mimicking this endogenous hormone , binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

Slowed gastric emptying alters the timing of B12 release, and changes in stomach acid production can impair intrinsic factor binding
