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A patient with a highly responsive GLP1R variant may experience nausea from peanut butter at doses where someone with a less responsive variant feels fine

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In human studies, a 52-wk semaglutide regimen did not affect P1NP levels but increased bone resorption marker CTx, leading to significant reductions in lumbar spine and total hip BMD (88)

Accessed February 13, 2025

However, individual responses to Saxenda vary considerably , and some patients report persistent or even increased hunger despite adherence to the prescribed dose escalation schedule