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Drucker had read about the work of endocrinologist John Eng, gastroenterologist Jean-Pierre Raufman and biochemist John Pisano, who had sequenced the proteins in Gila monster ( Heloderma suspectum ) venom and found two that looked like human GLP-1

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10.1038/s42255-019-0146-4 37 de JagerJ.KooyA.LehertP.WulffelM

SAR studies showed that this region of the molecule was the most sensitive to modification: even small changes to the substitution pattern on this ring significantly affected both receptor binding affinity and functional activity