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As a possible pharmacological target against T2D, GPR-120/GLP-1 signaling is gaining interest

The GLP-1 receptor/GIP receptor/GCGR triple agonist efocipegtrutide is presently under investigation in individuals with MASLD, and preclinical accounts of other dual and triple agonists that include GLP-1 receptor and GCGR agonism suggest that clinical studies in individuals with type 2 diabetes will follow [62, 63]

Author contributions Jennifer E Richard - Writing original draft, review & editing, Methodology - in vivo experiments, inflammation, metabolic hormones and PSD95 quantification, immunohistochemistry (IHC), Study design and funding acquisition, Statistical analysis

Both medications share the same slow dose escalation protocols to minimize side effects, and both show excellent long-term safety profiles