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4 PK strategy Rybelsus: steady exposure for glycaemic control Oral Wegovy: sustained appetite suppression Higher total exposure, with carefully controlled peaks 5 Regulatory reality Higher dose + new indication = new clinical package (and often a re-optimized formulation) This is treated as a new medicine, not a relabel.

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The current expanded analysis included sensitivity analyses of the primary end points, 6-minute walk distance, EQ-5D-5L health state index, Patient Global Impression of Severity Overall Health score, New York Heart Association class, use of heart failure medications, and a hierarchical composite based on all-cause death, worsening heart failure, and 52-week changes in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score and 6-minute walk distance