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The injectable medication is designed for long-term use, with Zepbound intended for ongoing treatment alongside a reduced-calorie diet and increased physical activity including aerobic exercise

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A recent publication from JAMA on the analysis of people who have been taking GLP-1 agonists from 2006 to 2020 shows that people who are taking GLP-1 agonists have a nine-fold higher risk of developing acute pancreatitis compared with the older drug for weight loss, bupropion, and four times more frequent intestinal obstruction and three times more frequent gastroparesis