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Novo Nordisk scientist Lotte Bjerre Knudsen's discoveries helped kick off a revolution in how doctors think of and treat obesity.

Methods This is a cohort study combining several population-wide databases and covering a Spanish population of five million inhabitants, including all adults with obesity who initiated treatment with either GLP-1RA or SGLT-2i for type 2 diabetes from 2015 to 2021

See mechanisms, side effects, expected outcomes, and how clinicians decide what fits best.