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Moving from 2.5mg to 5mg represents a doubling of the dose, and many people experience temporary nausea, reduced appetite beyond what is therapeutic, and sometimes diarrhea or constipation

Mild nausea, if present, typically resolves within the first week

Among people with less of the protein, called tau, slowing was most pronounced in those younger than 75 and those who did not yet have Alzheimers but had a pre-Alzheimers condition called mild cognitive impairment, according to data presented Monday at the Alzheimers Association International Conference in Amsterdam

Your maintenance dose is based on your progress, tolerance, and weight loss goals

When nausea persists beyond the usual adjustment window, clinicians commonly slow the pace of titration or pause at a tolerable dose, especially during the first 6 to 12 weeks when individual sensitivity and life stressors can amplify side effects