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The FDA, for decades, essentially gave them a free pass

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One RCT enrolled 64 chronically stressed adults who received 600 mg/day of KSM-66 root extract for 60 days, resulting in a 27.9% decrease in serum cortisol and significant reductions in stress scores compared with placebo [33]

Patients with documented hypersensitivity to tirzepatide components or those experiencing systemic symptomssuch as generalized urticaria, facial swelling, or difficulty breathingshould discontinue injections immediately and seek emergency care