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In another recent publication (126), it was shown that pretreatment with the dual-GLP-1/GIP receptor agonist DA3-CH or liraglutide could decrease the levels of ERS damage proteins (CHOP, GRP78,) and pro-apoptotic factors (Bax, Caspase12) as well as increase anti-apoptotic factor (Bcl-2), and reduce neuronal death and neurological damage after stroke in diabetic rats

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As the dosage gradually increases, appetite suppression often becomes stronger and more noticeable

Weight Loss Begins: Many individuals start to see more noticeable weight loss, often around 1-5% of their total body weight by the end of this phase

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