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Conclusion The use of SGLTis and GLP-1 RAs represents a paradigm shift in the management of HF, moving beyond their traditional role as drugs for diabetes

Consequently, a 30-pound weight loss could reduce knee loading by 90-120 pounds with each step, representing substantial mechanical relief

[11] Basen-Engquist, K., & Chang, M

In individuals with obesity and diabetes, the incretin effect is diminished, contributing to poor glucose tolerance

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