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For example, a randomised trial in patients with type 2 diabetes found that liraglutide (1.2 or 1.8 mg) significantly improved emotional well-being and general perceived health compared to glimepiride (8 mg daily) [4]

Dose escalation should always be a shared decision with your provider

This is a general pharmacokinetic principle based on the protein stability characteristics of each formulation

SURMOUNT-1 data shows that tirzepatide at the 10mg dose begins to plateau around 24 months as well, though higher doses may extend the active weight loss window somewhat further

The blood pressure-lowering effect may be partly mediated by weight loss, though other mechanisms may also contribute