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and outcomes: the primary outcome was the BMI reduction, mean days with headache, papilledema, visual disturbances and refractory or nonresponsive IIH

The key is not avoiding these medications entirely, but: Using appropriate monitoring Implementing preventive strategies Intervening early when problems arise Addressing metabolic effects while maintaining psychiatric stability Balancing risks and benefits: Untreated or inadequately treated depression carries serious risks: Disability and reduced functioning Lost work and relationships Physical health consequences (inflammation, cardiovascular risk) Suicide For many people, the benefits of effective antidepressant treatment outweigh the metabolic risks particularly when those metabolic risks are monitored and addressed

Clinical trials show the most dramatic reduction occurs during months 23 as your dose escalates

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Hermes HFpEF 16 ongoing trial that randomizes patients with HFpEF and HFmrEF to Ziltivekimab or placebo, and assesses time to first occurrence of cardiovascular death, heart failure hospitalization, or urgent heart failure visit Artemis Acute Ischemia 17 ongoing trial that randomizes patients hospitalized with MI to Ziltivekimab or placebo, and assess time to MACE