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Serious side effects Contrave can lead to rare and serious side effects: Seizures (especially with high-fat meals or certain pre-existing conditions) Liver problems Vision changes Low blood sugar Faster heart rate Increased blood pressure and heart rate Severe allergic reactions Angle-closure glaucoma Suicidal thoughts Although rare, some people taking Ozempic may experience serious side effects: Severe allergic reaction Hypoglycemia (low blood sugar) Kidney problems Vision changes (diabetic retinopathy) Pancreatitis (inflammation of the pancreas) Gallbladder problems Box warnings Contrave carries a boxed warning for increased risk of suicidal thoughts and behaviors, especially in young adults, due to its bupropion component