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Hypoglycemia risk increases when tirzepatide is combined with insulin or sulfonylureas, though the medication alone rarely causes low blood sugar due to its glucose-dependent mechanism

Manish Sahni, MD at Centra Internal Medicine Does tirzepatide only reduce weight, or does it also improve metabolic health (blood sugar, cholesterol, etc.)

They often bring HbA1c levels down by between 0.5 to 1%, although the actual decrease varies from person to person depending largely on their blood sugar at diagnosis and other medications they may be taking

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LDL cholesterol shows modest improvement while HDL (the protective cholesterol) tends to rise