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Feeding tubes or IV nutrition for severe cases

Still, GLP-3 does not describe a correct drug class

On the other hand, the risks of HHF (HR 0.93, 95% CI 0.831.04 with GLP-1RAs and HR 0.69, 95% CI 0.610.79 with SGLT2is) and composite kidney outcomes excluding macroalbuminuria (HR 0.92, 95% CI 0.801.06 with GLP-1RAs and HR 0.55, 95% CI 0.480.64 with SGLT2is) significantly reduced with SGLT2is only

While practical challenges including cost, access, and manufacturing constraints currently limit the widespread adoption of tirzepatide, the clinical evidence suggests that dual agonism represents the future direction of metabolic therapy

Effective weight management through a balanced diet, regular exercise, and professional guidance can lead to healthier outcomes and enhance quality of life