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However, benefits were still observed across the BMI spectrum, and the effects were generally consistent across multiple subgroups, including those with mildly reduced versus preserved ejection fraction, and those receiving versus not receiving other heart failure medications like mineralocorticoid receptor antagonists and SGLT2 inhibitors at baseline

9 (download XLSX Statistical source data for Extended Data Fig

As a GLP-1 receptor agonist, it mimics the hormone glucagon-like peptide-1 (GLP-1) to regulate blood sugar and appetite

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2.3 Variability in incretin receptor expression An important aspect of -cell heterogeneity is the variability in incretin receptor expression