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Constipation can also be accompanied by bloating and abdominal discomfort

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Therefore, it is likely that a once-weekly fixed-ratio combination of basal insulin and GLP-1 RA could help mitigate the inertia often associated with insulin initiation and relieve the treatment burden of daily injections [7,8,9]

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GIP (142) exhibits a notably brief plasma half-life of only a few minutes in healthy individuals, primarily due to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), generating GIP (342) [12]

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