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The superior cardioprotective effect of GLP-1 (7-36amide) relative to exendin-4 and the preservation of efficacy of GLP-1 (7-36amide) but not exendin-4 in GLP-1R KO mice suggest that some of the cardioprotective effects of GLP-1 (7-36amide) are independent of GLP-1R signaling and are potentially mediated via the DPP-4-cleaved GLP-1 metabolite GLP-1 (9-36amide) [201]

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What GLP-1 dry mouth research tells us about the future The growing recognition of GLP-1 related oral side effects is driving new research into targeted solutions

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