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She notes that "when people [generally] lose even a small amount of weight and improve their metabolic health, their risk of depression and anxiety goes down." This pattern existed before what she calls the "Ozempic revolution." In 2024, following an uptick in reports of suicidal thoughts and behaviors associated with GLP-1 use, the U.S

But we do know that the clinical study showed that when patients stopped the medicine, they did have weight regain

Suppressing glucagon release, reducing the liver's production of glucose