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When Testosterone Therapy May Still Be Needed Testosterone therapy may remain appropriate for men who: have persistently low levels despite weight loss experience ongoing symptoms affecting quality of life have confirmed primary hypogonadism do not respond adequately to metabolic interventions In some cases, combining lifestyle strategies, metabolic treatment, and hormone therapy provides the best outcome
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Renal elimination of unchanged orforglipron is minimal, suggesting that dose adjustment in patients with renal impairment may not be necessary
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