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Moreover, cardiometabolic effects of GLP-1 are attenuated in obesity and T2D, via mechanisms that may involve impaired p38-MAPK signaling

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The antidepressant effects of GLP-1 receptor agonists: A systematic review and Meta-Analysis

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For safety outcomes, semaglutide and tirzepatide showed lower risks for serious bacterial infections compared to sitagliptin and dulaglutide, respectively

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Cardiovascular Risk Reduction# Recommendation : Semaglutide Reason : SELECT demonstrated 20% MACE reduction with semaglutide in 17,604 patients

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