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Switching is possible but must be managed carefully by a healthcare professional

Clinical studies show that patients on the 2.4 mg/week dose achieve greater and more sustained weight loss compared to lower doses
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It is believed that reduced concentrations of GLP-1 would result in loss of the pro-kinetic actions of GLP-1 in the colon [Citation26], causing constipation and abdominal discomfort, was further supported by the correlation between this and the intensity of abdominal pain (12)

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