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Affected individuals report experiencing serious health complications including stomach paralysis requiring hospitalization, persistent vomiting lasting four weeks or more, severe bowel obstructions, blood clots, and permanent vision loss injuries they claim were not disclosed on the drugs labeling

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Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

However, due to the nausea often associated with these drugs, initiating treatment at a lower dose and gradually increasing it can improve tolerability