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From a neuroscience perspective, less adiposity means less peripheral inflammation, less mechanical joint stress, less nociceptor drive, and potentially less central sensitization

This natural increase in activity creates a positive feedback loop, further strengthening heart health

Talk with your healthcare provider about the benefits and risks before using these medicines while breastfeeding

Surgery, on the other hand, provides a metabolic reset for people who need more dramatic or permanent weight loss

Overall, the multimorbidity of depression and T2DM involves shared genetic risk factors and multiple underlying biological mechanisms, including HPA axis dysregulation, pro-inflammatory states, gut-brain axis interactions, and insulin signaling alterations, which can affect neurotransmission