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Leading contributors to CKD such as inflammation, fibrosis, and hypoxia are reduced by these metabolic adaptations

Zepbound is indicated for adults with obesity (with a BMI of 30 kg/m2 or greater), or those who are overweight (with a BMI of 27 kg/m2 or greater) and also have weight-related medical problems such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea or cardiovascular disease, to lose weight and keep it off

Although glycogen synthesis and intracellular glycogen levels proportionally inhibit AMPK activity [86], the increase in glycogen seen in patients receiving GLP-1 agonists may be partially due to GLP-1R/AMPK activation that overrides basal glycogen inhibition of AMPK

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