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In practice, American adults take GLP-1s for an average of 6 months

However, some users report changes in their mood, including increased irritability

Some GLP-1 analogues may influence glutamatergic and GABAergic pathways, potentially contributing to therapeutic effects in conditions such as epilepsy, autism spectrum disorders, and addiction, although further validation is required

Scientific References Frequently Asked Questions Can Mounjaro cause low blood sugar and shakiness

CrossRef Evaluating Cardio-Protective Molecules by Efficacy Based on Weight Reduction and HbA1c Targets Teodor Salmen, Valeria-Anca Pietrosel, Flaviana-Veronica Urzica, Diana-Elena Visan, Bianca-Margareta Salmen, Radu-Cristian Cimpeanu, Delia Reurean-Pintilei, Mihaela-Simona Popoviciu, Anca Pantea Stoian Biomedicines.2025