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In vivo Release Pharmacokinetic of PSR-MNs for semaglutide After characterizing the mechanical properties and in vitro release profiles of PSR-MNs, we proceeded to evaluate these microneedles in a rat model

However, analysis of trial data from five long-acting GLP-1 agonists (exenatide once weekly, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC) revealed that they were more likely than shorter-acting formulations to raise the heart rate (Robinson et al., 2013)
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