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In effect, where a GLP-1 medication addresses the appetite and metabolic signalling side of the equation, apitegromab appears to address the musculoskeletal side directly, and the early data suggests the two mechanisms may complement each other more effectively than either does alone

Comparative safety assessment demonstrated a statistically significant reduction in adverse reaction incidence with combination therapy (GLP-1 receptor agonists plus metformin) compared to monotherapy

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