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To accommodate GLP-2 rather than GLP-1, GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices (TMs) 1, 5, 7 and extracellular loop 1 (ECL1)

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Growing evidence suggests that GLP-1 receptor agonists like semaglutide may offer unexpected benefits beyond weight loss, including potential migraine relief through metabolic and inflammatory pathways

Weight management (and the treatment of weight-related comorbidities) is not one-size-fits-all