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It was reported that the weight loss property (5-10%) of GLP-1 analogs is hampered by dose-dependent side-effects 10

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The observational design of the study allows for potential confounding of results as it does not take into account socioeconomic status, physical activity levels, dietary quality, and health-seeking behavior from the persons evaluated, Carcas, who was not involved in this study, explained

This provides conservative, real-world estimates