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169 Ghrelin also mediates insulinostatic actions even though human beta-cells do not express any known receptors for ghrelin, but a recent study discovered that the ghrelin receptor is expressed solely by delta-cells, implying that ghrelin dampens insulin secretion by inducing somatostatin release

Some researchers push as high as 2.0 grams per kilogram, though diminishing returns set in beyond 1.6 for most people

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If GI symptoms persist despite these strategies, some users explore split dosing (microdosing) to reduce peak concentration and smooth out the dose response
