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What the preclinical signal tells us One of the clearest historical preclinical signals comes from a rat study indexed in PubMed

We observed that 83% of the eluted peptides contained a predicted 9-mer binding core restricted to the appropriate HLA haplotype, highlighting a good alignment between EpiMatrix prediction and MAPPs data

25 The frequent adverse event in the OCA group was pruritus (33 patients, 23%), and only one patient had treatment discontinuation

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doi: 10.1016/j.pneurobio.2013.04.004 [DOI] [PMC free article] [PubMed] [Google Scholar] 177.Hong CT, Chen KY, Wang W, et al