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17 A metaanalysis of four studies reported a nonsignificant relative risk of 0.568 (95% CI: 0.0774.205)

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The binding of leptin to circulating leptin-binding proteins inhibits the leptin transport to the CNS, suppresses the interaction between leptin and LepR neurons, and induces leptin resistance-related phenotypes [209]

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Clinicians evaluate potential interactions, cumulative side effects, and overall adherence
