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A flexible segment in DPP-4 connects the transmembrane domain to the extracellular domain and is the target of shedding, a process in which the enzyme is cleaved and released into circulation [22]

In head-to-head trial data, tirzepatide produced larger average weight loss than semaglutide over comparable periods

Tirzepatide is a once-weekly injection available as two brands: Zepbound (for weight loss, weight management, and obstructive sleep apnea) and Mounjaro (for type 2 diabetes)

Focusing on a protein-rich diet and getting regular exercise may help preserve some of the benefits

AugsteinPNaselliGLoudovarisTHawthorneWJCampbellPBandala-SanchezEet al