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32,47 The key factors increasing cell death include endoplasmic reticulum stress (leading to accumulation of unfolded and misfolded proteins within this key subcellular compartment critical in the biosynthesis of secretory and structural proteins as well as steroids, cholesterol, and other lipids), oxidative stress, mitochondrial dysfunction, inflammatory stress, and inclusions of aggregated peptides that reside within a similar intracellular milieu as do neuronal cells in PD

Pooled mean follow-up on-treatment for semaglutide users was 193 days (median 157 days, interquartile range (IQR) 85 to 331 days) and for sitagliptin users 195 days (median 160 days, IQR 95 to 322 days)

This distension can trigger accelerated lower intestinal transit as your gut tries to make room, resulting in loose stools

doi:10.1073/pnas.89.18.8641 9

That said, the landscape is far from limited