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Because GLP-1 therapies improve insulin regulation systemically, they may also enhance signaling pathways in the central nervous system
Diabetes 61(5):12501262 Girardi AC, Degray BC, Nagy T, Biemesderfer D, Aronson PS (2001) Association of Na+-H+ exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule

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Nat Rev Gastroenterol Hepatol 14:110121 Sobczak M, Fabisiak A, Murawska N, Wesoowska E, Wierzbicka P, Wlazowski M, Wjcikowska M, Zatorski H, Zwoliska M, Fichna J (2014) Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases
