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Another cohort study of the same TriNetX database found that 193 IIH patients taking tirzepatide had a reduction in BMI of 1.147 mm/kg 2 greater than 193 controls (18)
Because I am always about how do we intervene with the things that [00:43:00] you don't require from me
As there is no meaningful expression of GLP-1 receptors on hepatocytes, the major effect of GLP-1 agonists on MASH is likely to be indirect and may be related to a reduction in calorie intake, body weight and insulin resistance, all of which would lead to reduced liver lipid accumulation and hepatic inflammation 7,8
