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The weight-loss drugs, which include Wegovy (semaglutide) and Zepbound (tirzepatide), have become more accessible than ever thanks to recent price cuts, expanding Medicare and Medicaid access, and (more controversially) compounded options from online pharmacies and health startups

There is no established lethal dose of semaglutide in humans, and the medication does not typically cause respiratory depression or loss of consciousness

The goal is not a magic number of glasses

Conversion optionality (the ability to execute a product-hopping strategy) is not always priced into LOE-discounted acquisition targets, creating potential for acquirers with strong lifecycle management capabilities

On the other hand, if GLP-1 therapy reduces your baseline IBS-D episodes long-term, you might judge that a few days of mild loose stools during dose titration is a price worth paying